Maxim Shkurnikov
- Deputy Dean:Faculty of Biology and Biotechnology
- Associate Professor:Faculty of Biology and Biotechnology / Joint Department with RAS Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Laboratory Head:Faculty of Biology and Biotechnology / Laboratory for Research on Molecular Mechanisms of Longevity
- Programme Academic Supervisor:Cell and Molecular Biotechnology
- Maxim Shkurnikov has been at HSE University since 2020.
Education and Degrees
- 2009
Candidate of Sciences* (PhD)
- 2004
Degree in Medical Cybernetics
Russian State Medical University
According to the International Standard Classification of Education (ISCED) 2011, Candidate of Sciences belongs to ISCED level 8 - "doctoral or equivalent", together with PhD, DPhil, D.Lit, D.Sc, LL.D, Doctorate or similar. Candidate of Sciences allows its holders to reach the level of the Associate Professor.
Awards and Accomplishments
Winner of the HSE University Best Russian Research Paper Competition – 2022
Courses (2023/2024)
- Mentor's Seminar (Master’s programme; Faculty of Biology and Biotechnology; 1 year, 1-4 module)Rus
- Project Seminar (Bachelor’s programme; Faculty of Biology and Biotechnology; 3 year, 3 module)Rus
- Past Courses
Courses (2022/2023)
Courses (2021/2022)
Publications25
- Article Zhiyanov A., Narek Engibaryan, Nersisyan S., Shkurnikov M., Tonevitsky A. Differential co-expression network analysis with DCoNA reveals isomiR targeting aberrations in prostate cancer // Bioinformatics. 2023. Vol. 39. No. 2. Article btad051. doi
- Article Shkurnikov M., Nersisyan S., Averinskaya D., Chekova M., Poljakov F., Tonevitsky A. HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire // PeerJ. 2023. Vol. 11. Article e14707. doi
- Article Zhiyanov A., Shkurnikov M., Nersisyan A., Hui C., Baranova A., Tonevitsky A. The signature of SARS-CoV-2 evolution reflects selective pressures within human guts // Journal of Medical Virology. 2023. Vol. 95. No. 8. Article e28996. doi
- Article Nersisyan S., Zhiyanov A., Zakharova M., Ishina I., Kurbatskaia I., Mamedov A., Galatenko A. V., Shkurnikov M., Gabibov A., Tonevitsky A. Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules // PeerJ. 2022. Vol. 10. Article e13354. doi
- Article Titov A., Shaykhutdinova R., Shkurnikov M., Nersisyan S., Tonevitsky A. Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2 // JCI insight. 2022. Vol. 7. No. 9. Article e157699. doi
- Article Nersisyan S., Zhiyanov A., Shkurnikov M., Tonevitsky A. T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations // Nucleic Acids Research. 2022. Vol. 50. No. D1. P. D883-D887. doi
- Article Gladkova A., Argylov N., Shkurnikov M. The interplay between digital and social inclusion in multiethnic Russian society: An empirical investigation // European Journal of Communication. 2022. Vol. 37. No. 6. P. 606-628. doi
- Article Nersisyan S., Gorbonos A., Alexey Makhonin, Zhiyanov A., Shkurnikov M., Tonevitsky A. isomiRTar: a comprehensive portal of pan-cancer 5′-isomiR targeting // PeerJ. 2022. Vol. 10. Article e14205. doi
- Article Шкурников М. Ю., Комаров А. Г., Карбышев И. А., Спешилов Г. И., Штинова И. А., Дорошенко Д. А., Вечорко В. И. ВЗАИМОСВЯЗЬ ПРОГНОЗА ТЕЧЕНИЯ COVID-19 С МУТАЦИЯМИ БЕЛКА NS8 SARS-COV-2 В ЗАВИСИМОСТИ ОТ ШТАММОВОЙ ПРИНАДЛЕЖНОСТИ ВИРУСА // Доклады Академии наук. 2022. Т. 507. № 1. С. 460-464. doi (in press)
- Article Шкурников М. Ю., Комаров А. Г., Карбышев И. А., Спешилов Г. И., Штинова И. А., Дорошенко Д. А., Вечорко В. И., Драпкина О. М. Взаимосвязь генотипа главного комплекса гистосовместимости класса I с летальностью COVID-19 у пациентов с сахарным диабетом // Доклады Академии наук. 2022. Т. 507. № 6. С. 515-519. doi (in press)
- Article Жиянов А. П., Шкурников М. Ю. Мутации SARS-CoV-2 приводят к снижению числа регионов связывания с микроРНК ткани лёгких // Клеточные технологии в биологии и медицине. 2022. № 4. С. 216-221. doi
- Article Shkurnikov M., Nersisyan S., Jankevic T., Galatenko A. V., Gordeev I., Vechorko V., Tonevitsky A. Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19 // Frontiers in Immunology. 2021. Vol. 12. Article 641900. doi
- Article J. Makarova, Turchinovich A., M. Shkurnikov, A. Tonevitsky. Extracellular miRNAs and cell-cell communication: problems and prospects // Trends in Biochemical Sciences. 2021. Vol. 46. No. 8. P. 640-651. doi
- Article Knyazev E., Maltseva D., Raigorodskaya M., Shkurnikov M. HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease // Frontiers in Genetics. 2021. Vol. 12. Article 791640. doi
- Article Nersisyan S., Galatenko A. V., Galatenko V. V., Shkurnikov M., Tonevitsky A. miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence // Plos One. 2021. Vol. 16. No. 4. Article e0249424. doi
- Article Nersisyan S., Shkurnikov M., Poloznikov A., Turchinovich A., Burwinkel B., Anisimov N., Tonevitsky A. A post-processing algorithm for miRNA microarray data // International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228. doi
- Article Shkurnikov M. Yu., Nersisyan S. A., Osepyan A. S., Maltseva D. V., Knyazev E. N. Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples // Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 208-210. doi
- Article S. A. Nersisyan, M. Yu. Shkurnikov, E. N. Knyazev. Factors Involved in miRNA Processing Change Its Expression Level during Imitation of Hypoxia in BeWo b30 Cells // Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 205-207. doi
- Article Nersisyan S., Shkurnikov M., Turchinovich A., Knyazev E., Tonevitsky A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 // Plos One. 2020. Vol. 15. No. 7. P. e0235987. doi
- Article Shkurnikov M. Yu., Knyazev E. N., Fomicheva K. A., Kasatkin M. S., Arkov V. V., Makarova Yu. A. Detection of Low-Abundant MicroRNAs with Hybridization Microchips // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 6. P. 788-792. doi
- Article Shkurnikov M. Human Platelet Lysate Sustains the Osteogenic/Adipogenic Differentiation Potential of Adipose-Derived Mesenchymal Stromal Cells and Maintains Their DNA Integrity in vitro // Cells Tissues Organs. 2019. Vol. 207. No. 3-4. P. 149-164. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 8. P. 122. doi
- Article Galatenko V. V., Galatenko A. V., Samatov T., Turchinovich A., Shkurnikov M., Makarova Julia A, Tonevitsky Alexander G. Comprehensive network of miRNA-induced intergenic interactions and a biological role of its core in cancer // Scientific Reports. 2018. Vol. 8. Article 2418. doi
- Article Ernst A., Putscher A., Samatov T. R., Suling A., Galatenko, V. V., Shkurnikov, M. Y., Knyazev, E. N., Tonevitsky, A. G., Haalck T., Lange T., Schröder-Schwarz J., Riecken K., Schumacher U., Wicklein D. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy // Plos One. 2018. Vol. 13. No. 2. Article e0192525. doi
- Article Alekseev B., Knyazev E., Shkurnikov M., Mikhailenko D., Zotikov A., Nyushko K., Tonevitsky A., Kaprin A. Panel of 6 microRNAs for minimally invasive diagnosis of prostate cancer // Journal of Urology. 2017. Vol. 197. No. 4S. P. e341. doi
Editorial board membership
2016: Member of the Editorial Council, Бюллетень экспериментальной биологии и медицины Bulletin of Experimental Biology and Medicine (Bulletin of Experimental Biology and Medicine).
Paper by HSE Biologists Included in the Top 5 Popular Articles of PeerJ Journal
An article by researchers from HSE University’s Faculty of Biology and Biotechnology is among the most read articles published in the PeerJ journal in 2023. In the paper, the researchers establish a link between the genetic characteristics of the human immune system and its ability to effectively resist new waves of COVID-19. PeerJ is a peer-reviewed open access scientific journal covering research in the field of biological and medical sciences. Every year the editors compile a ranking of the most popular scientific papers.
From Cultural Appropriation to Prison Jargon: Second Semi-Final of Science Battles Takes Place at HSE University
On March 19, the second semi-final of the fourth season of HSE University Science Battles brought together the topics of cultural appropriation, pharmacological neural networks, prison jargon, and ‘diseases’ of higher education on the same stage. Students from various degree programmes presented their projects in the Community space. Read on to find out more about the performances featured in the semi-finals.
Seminar: gene overexpressionSeminar
On June 24, 2022, the International Laboratory of Microphysiological Systems hosted a joint seminar with the Laboratory for Research on the Molecular Mechanisms of Longevity, dedicated to the issue of miRNA overexpression in human cells, a process that leads to an excess amount of transcript produced by the genome.
Russian Researchers Assess the Power of T-Cell Immune Response to Omicron BA.1 and BA.2
Scholars from HSE University and the RAS Institute of Bioorganic Chemistry have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2. In approximately 90% of vaccinated Europeans, T-cell immunity was as effective against Omicron as with other variants. The results of the study were published in PeerJ.
Laboratory for Molecular Mechanisms of Ageing Opens at HSE University
The decision to create the laboratory was based on the results of an open competition organised by HSE University. The winner of the competition was the project ‘The role of non-coding RNA in facilitating active ageing’ led by Maxim Shkurnikov, Associate Professor of the HSE University Faculty of Biology and Biotechnology.
Russian Scientists Investigate the Immune Response to SARS-CoV-2 Variants
HSE University researchers assessed the effectiveness of the T-cell immune response to 11 variants of SARS-CoV-2. Their findings have been published in Nucleic Acids Research.
Researchers Reveal Genetic Predisposition to Severe COVID-19
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.