Analysis of the miRNA Interaction on the SARS-CoV-2 Genome Mutations since the Beginning of the COVID-19 Pandemic

Student: Belaya Anna

Faculty: Faculty of Biology and Biotechnology

Educational Programme: Cellular and Molecular Biotechnologies (Bachelor)

Final Grade: 8

Year of Graduation: 2024

SARS-CoV-2 research has been relevant in recent years due to the outbreak of the pandemic in 2019, which is why various factors related to the coronavirus are now being studied. Among these factors, microRNAs with broad regulatory potential are of particular interest. microRNA has an effect on the replication of the virus in the host cell, so this area of research is now developing. Understanding the interaction of microRNA with viral mRNA at the molecular level can help implement new drugs to combat SARS-CoV-2. In this work, the frequency of SARS-CoV-2 mutations was analyzed and the regions of the virus genome that mutated with the highest frequency were identified. microRNAs whose sites disappear during the evolution of the virus and their effect on the translation of SARS-CoV-2 mRNA have also been identified.

Full text (added May 20, 2024)

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