The Regulation of Cell Death Pathways in Cancer by the Interaction Between ADAR and PRKRA

Student: Voytetskiy Artem

Educational Programme: Data Analysis for Biology and Medicine (Master)

Year of Graduation: 2024

RNA sequencing (RNA-seq) is a powerful tool for studying gene expression and regulation. In this research project, we set out to study the effects of knockout of the ADAR and PRKRA genes, as well as the effect of interferon on the transcriptome. These genes play an important role in the regulation of RNA and interferon response, which makes them promising targets for therapeutic interventions. It was found that ADAR has a significant effect on RNA editing, and knockout of ADAR and PRKRA leads to changes in the expression of their associated genes. A particularly close relationship was found between the results of the study and lung cancer. The findings are supported by recent scientific publications. This work provides valuable information about the regulatory networks controlled by the ADAR and PRKRA genes. These results open up new opportunities for the development of effective therapeutic approaches to the treatment of oncological diseases.

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