Volume of R&D funding and number of Scopus-indexed publications of the BRICS countries in total already exceed those of the EU-total and the United States. These metrics have opportunity for further growth if the five developing countries strengthen scientific cooperation with other countries from Global South that have significant growth potential. Researchers from the Institute for Statistical Studies and Economics of Knowledge Alexander Sokolov, Sergey Shashnov, and Maxim Kotsemir analysed the opportunities for research collaboration within these clusters of countries along with the obstacles standing in the way of greater cooperation.