HSE researchers, in collaboration with their colleagues from Skoltech and the Central Research Institute for Epidemiology, have uncovered the mechanisms behind the emergence of new and dangerous coronavirus variants, such as Alpha, Delta, Omicron, and others. They have discovered that the likelihood of a substitution occurring at a specific site of the SARS-CoV-2 genome is dependent on concordant substitutions occurring at other sites. This explains why new and more contagious variants of the virus can emerge unexpectedly and differ significantly from those that were previously circulating. The study’s findings have been published in
eLife.