As part of the promotion of modern supercomputer technologies for the needs of scientific research, SAMMA laboratory organized the second school-seminar "Supercomputers in scientific research: the horizons of multi-scale modeling and effective supercomputer co-design". This event brings together developers of advanced supercomputer technologies and scientists who use high-performance computing in their research. The first day was devoted to the analysis of new technical solutions for high-performance computing, and the second to applications of supercomputer modeling, molecular dynamics simulations in the real problems of materials science and molecular biology.