Evgeny Knyazev

In the article “Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies,” Russian scientists have presented an overview of modern cellular models of preeclampsia—a dangerous pregnancy complication. The study covers two-dimensional and three-dimensional cultures, as well as advanced placenta-on-a-chip microfluidic technologies, allowing the examination of pathological mechanisms at the cellular level. The paper highlights the potential of CRISPR-Cas9 and personalized models for developing new diagnostic and therapeutic methods for preeclampsia. These advancements open prospects for more precise early diagnosis of preeclampsia and the creation of effective treatment strategies.

The Moscow Young Scientists Club was established as part of the "At the Center of Science" project, organized by the Center for Pedagogical Excellence with funding from the Moscow Department of Education and Science.

This project, organized by the Moscow Department of Education and Science with the support of the Center for Pedagogical Excellence and other institutions, includes lectures, workshops, and educational intensives featuring science communicators and leading scientists from across Russia.

During the session “Microfluidic Technologies: Will Organ-on-Chip Replace In Vivo Studies?”, Evgeny Knyazev presented the laboratory’s research projects, including:
Development of an in vitro intestine-on-a-chip model with physiologic permeability characteristics;
RSF grant project: Microfluidic placenta-on-a-chip model for the study of preeclampsia.

The textbook titled “Professional Training Internship: Year 1 – A Practical Guide for Students and Educators” by Knyazev E.N. and Chebotareva O.E. has been honored in HSE University's academic achievement awards for its contribution to the institution’s reputation (Level 2).

Ahead of the new academic year, Evgeny Knyazev, Head of the Molecular Physiology Laboratory at the Faculty of Biology and Biotechnology, led an interactive discussion on "The Role of Scientific Conferences in a Scientist's Career."

The winners are determined by student voting

As part of the special session "Study of Safety and Biomarkers of New Drugs," a report was given on "The Use of the 'Human-on-a-Chip' Platform in Drug Development"

The project to develop a microfluidic placenta-on-a-chip model for studying various aspects of normal and pathological placental physiology, including one of the severe pregnancy complications—preeclampsia—has won in the competition "Conducting Fundamental and Exploratory Scientific Research by Individual Scientific Groups"

The article "MicroRNA miR-27a as a possible regulator of anti-inflammatory macrophage phenotype in preeclamptic placenta" identified a potential therapeutic target for treating preeclampsia.

The "Leaders of Russia" competition is an initiative supported by the President of the Russian Federation and a cornerstone project of the "Russia - a country of opportunities" platform

From November 26 to December 1, the Scientific Leaders' Offsite School and the III Congress of Young Scientists took place in Sochi and the Sirius Park of Science and Art. Evgeny Knyazev, a member of the Faculty of Biology and Biotechnology at HSE University, participated in these events.